Summary
Abstract Our group and others have previously identified TTF-1/NKX2-1 as a lineage survival oncogene in lung adenocarcinoma. Subsequent studies revealed double-edged sword characteristics of TTF-1 in the development of lung adenocarcinoma. TTF-1 elicits lineage-survival signaling by inducing transcriptional targets such as ROR1, while TTF-1 also inhibits tumor progression by decreasing cell motility through direct activation of genes such as MYBPH. It is thus clear that a more comprehensive picture of this still enigmatic lineage-survival oncogene needs to be elucidated. Whereas most of the previous studies on TTF-1 have focused on its regulation of protein-coding genes, very little is known about regulation of microRNAs by TTF-1. In the present study, we combined in vivo patient data with
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