Summary
Abstract We previously reported that the receptor tyrosine kinase-like orphan receptor 1 (ROR1) is transcriptionally activated by TTF-1/NKX2-1 lineage-survival oncogene in lung adenocarcinoma and maintains a favorable balance between pro-survival PI3K-AKT and pro-apoptotic ASK1-p38 signaling. Although in-depth mechanistic insight into how ROR1 sustains EGFR-mediated PI3K-AKT signaling in both kinase-dependent and -independent manners has been obtained, it remains elusive how ROR1 inhibits pro-apoptotic signaling. In the present study, we investigated the underlying mechanism of ROR1-mediated inhibition of the ASK1-p38MAPK signaling pathway. Co-treatment with siASK1 resulted in partial but significant alleviation of siROR1-mediated growth inhibition in the lung adenocarcinoma cell lines PC-
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