Summary
Multi-isotope imaging in vivo is an appealing molecular imaging approach that provides extensive information about molecular pathways that cannot be accessed in usual imaging methods with a single radioactive probe. However, conventional imaging systems have limited energy resolution; as a result, the images obtained from multi-isotope imaging are associated with problems, such as nonnegligible noise and spectral crosstalk, owing to the photons emitted from radioisotopes being simultaneously used in the experiments. This study proposes a novel small-animal SPECT system, called CdTe-DSD SPECT-I, based on the cadmium telluride double-sided strip detector (CdTe-DSD), which was originally developed to observe high-energy X-rays and gamma rays in space. The detector has an energy resolution of
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