Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Genetic mechanisms of critical illness in COVID-19

The GenOMICC Investigators, Erola Pairo‐Castineira, The ISARIC4C Investigators, The COVID-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Sara Clohisey, Lucija Klarić, Andrew D. Bretherick, Konrad Rawlik, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D Russell, James Furniss, Anne Richmond, Viktoria‐Eleni Gountouna, Nicola Wrobel, David A Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme R. Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Seán Keating, Marie Zechner, Chris Haley, David J. Porteous, Caroline Hayward, Jian Yang, Julian C. Knight, Charlotte Summers, Manu Shankar‐Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C. Moore, Charles Hinds, Peter Horby, Alistair Nichol, David M. Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alexandre C. Pereira, Alessandra Renieri, Xia Shen, Chris P. Ponting, Angie Fawkes, Albert Tenesa, Mark J. Caulfield, Richard H. Scott, Kathy Rowan, Lee Murphy, Peter Openshaw, Malcolm G. Semple, Andrew Law, Véronique Vitart, James F. Wilson, J. Kenneth Baillie

Nature · 2020

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Summary

Host-mediated lung inflammation is present<sup>1</sup>, and drives mortality<sup>2</sup>, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development<sup>3</sup>. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10<sup>-8</sup>) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10<sup>-8</sup>) near

Source type
Peer-reviewed study
DOI
10.1038/s41586-020-03065-y
Catalogue ID
BFmoakvpzf-1nupha
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