Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition
Liesl Wandrag, Mario Siervo, Heather L. Riley, Maryam Khosravi, Bernadette Fernandez, Carl A. Leckstrom, Daniel Martín, Kay Mitchell, Denny Levett, Hugh Montgomery, Monty Mythen, M Stroud, Michael P. W. Grocott, Martin Feelisch
The putative role of GLP-1 and nitrite as mediators of the effects of hypoxia on FFM is an intriguing finding. If confirmed, nutritional and pharmacological interventions targeting these pathways may offer new avenues for prevention and treatment of sarcopenia.
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