Physiological responses during ascent to high altitude and the incidence of acute mountain sickness

Alexandra Cobb, Denny Levett, Kay Mitchell, W Aveling, Daniel Hurlbut, Edward T. Gilbert-Kawai, P. J. Hennis, Monty Mythen, Michael P. W. Grocott, Daniel Martín, Caudwell Xtreme Everest, Xtreme Everest 2009, Xtreme Everest 2 investigators, Vineet Ahuja, Golnar Aref-Adib, Robert Burnham, Alexandra Chisholm, Kieran Clarke, David Coates, Matthew Coates, Derek G. Cook, Mark Cox, S Dhillon, C Dougall, Pat Doyle, Pamela W. Duncan, Mark Edsell, Laura Edwards, Lauren Evans, Peter Gardiner, Michael P. W. Grocott, P Gunning, Nicholas Hart, Jane Harrington, John Julian Harvey, C Holloway, Diantha B. Howard, David Hurlbut, Chris Imray, Can İnce, Jildou van der Kaaij, Maryam Khosravi, Nicky Kolfschoten, D Levett, H Luery, Andrew M. Luks, Daniel Martín, Roger McMorrow, Paula Meale, Kay Mitchell, Hugh Montgomery, Gareth J. Morgan, J Morgan, Andrew J. Murray, M Mythen, Stanton Newman, Michael O’Dwyer, James W. Pate, Timothy Plant, Matiram Pun, Paul Richards, Alan Richardson, George W. Rodway, John B. Simpson, Catherine Stroud, M Stroud, J Stygal, Barbara Symons, Piotr Szawarski, A Van Tulleken, Chris van Tulleken, André Vercueil, Liesl Wandrag, Mark H. Wilson, Jeremy S. Windsor, B Basnyat, Caroline S. Clarke, Thomas F. Hornbein, James S. Milledge, James A. West, Sabu Abraham, Tom Adams, W Anseeuw, Rónan Astin, B Basnyat, Oliver Burdall, Janet T. Carroll, Alistair R.M. Cobb, Jonny Coppel, Orestes Couppis, J. H. Court, Andrew F. Cumpstey, Thomas Davies, S Dhillon, Norman G. Diamond, C Dougall, T Geliot, Edward T. Gilbert-Kawai, Grace Gilbert-Kawai, Erich Gnaiger, Michael P. W. Grocott, C Haldane

Physiological Reports · 2021

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Summary

Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim of this study was to describe the relationship between physiological variables and the incidence of AMS during ascent to 5300 m. A total of 332 lowland-dwelling volunteers followed an identical ascent profile on staggered treks. Self-reported symptoms of AMS were recorded daily using the Lake Louise score (mild 3-4; moderate-severe ≥5), alongside measurements of physiological variables (heart rate, respiratory rate (RR), peripheral oxygen saturation (SpO<sub>2</sub> ) and blood pressure) before and after a standardised Xtreme Everest Step-Test (XEST). The overall occurrence of AMS among participants was 73.5% (23.2% mild, 50.3% moderate-severe). There was no difference in gender, age, pr

Source type: Peer-reviewed study
DOI: 10.14814/phy2.14809
Catalogue ID: BFmoakvpzf-lr7d3e

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