Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

Jack Bowden, Fabiola Del Greco M, Cosetta Minelli, George Davey Smith, Nuala A. Sheehan, John R. Thompson

International Journal of Epidemiology · 2016

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Summary

: Care must be taken to assess the NOME assumption via the IGX2 statistic before implementing standard MR-Egger regression in the two-sample summary data context. If IGX2 is sufficiently low (less than 90%), inferences from the method should be interpreted with caution and adjustment methods considered.

Source type
Peer-reviewed study
DOI
10.1093/ije/dyw220
Catalogue ID
BFmoef2ocf-0v4jmi
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