Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study

Robert Carreras‐Torres, Mattias Johansson, Philip Haycock, Kaitlin H. Wade, Caroline L. Relton, Richard M. Martin, George Davey Smith, Demetrius Albanes, Melinda C. Aldrich, Angeline S. Andrew, Susanne M. Arnold, Heike Bickeböller, Stig E. Bojesen, Hans Brunnström, Jonas Manjer, Irene Brüske, Neil E. Caporaso, Chu Chen, David C. Christiani, W. Jay Christian, Jennifer A. Doherty, Eric J. Duell, John K. Field, Michael P.A. Davies, Michael W. Marcus, Gary E. Goodman, Kjell Grankvist, Aage Haugen, Yun‐Chul Hong, Lambertus A. Kiemeney, Erik H.F.M. van der Heijden, Peter Kraft, Mikael B. Johansson, Stephen Lam, Maria Teresa Landi, Philip Lazarus, Loı̈c Le Marchand, Geoffrey Liu, Olle Melander, Sungshim L. Park, Gad Rennert, Angela Risch, Eric B. Haura, Ghislaine Scélo, Давид Заридзе, Anush Mukeriya, Milan Savić, Jolanta Lissowska, Beata Świątkowska, Vladimír Janout, Ivana Holcátová, Dana Mateș, Matthew B. Schabath, Hongbing Shen, Adonina Tardón, M. Dawn Teare, Penella J. Woll, Ming‐Sound Tsao, Xifeng Wu, Jian‐Min Yuan, Rayjean J. Hung, Christopher I. Amos, James McKay, Paul Brennan

PLoS ONE · 2017

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Summary

Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.

Source type: Peer-reviewed study
DOI: 10.1371/journal.pone.0177875
Catalogue ID: BFmoef2ocf-jsofzd

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