Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Variation in<i>PCSK9</i>and<i>HMGCR</i>and Risk of Cardiovascular Disease and Diabetes

Brian A. Ference, Jennifer G. Robinson, Robert D. Brook, Alberico L. Catapano, M. John Chapman, David Neff, Szilárd Vörös, Robert P. Giugliano, George Davey Smith, Sergio Fazio, Marc S. Sabatine

New England Journal of Medicine · 2016

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Summary

In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive. (Funded by the Medical Research Council and the National Heart, Lung, and Blood Institute.).

Source type
Peer-reviewed study
DOI
10.1056/nejmoa1604304
Catalogue ID
BFmoef2ocf-swtvym
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