Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Inflammatory Biomarkers and Risk of Schizophrenia

Fernando Pires Hartwig, Maria Carolina Borges, Bernardo Lessa Horta, Jack Bowden, George Davey Smith

JAMA Psychiatry · 2017

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Summary

Under mendelian randomization assumptions, our findings suggest a protective effect of CRP and a risk-increasing effect of sIL-6R (potentially mediated at least in part by CRP) on schizophrenia risk. It is possible that such effects are a result of increased susceptibility to early life infection.

Source type
Peer-reviewed study
DOI
10.1001/jamapsychiatry.2017.3191
Catalogue ID
BFmoef2ocf-tdx1mh
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