Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Systematic identification of genetic influences on methylation across the human life course

Tom R. Gaunt, Hashem A. Shihab, Gibran Hemani, Josine L. Min, Geoff Woodward, Oliver Lyttleton, Jie Zheng, Aparna Duggirala, Wendy L. McArdle, Karen Ho, Susan M. Ring, David M. Evans, George Davey Smith, Caroline L. Relton

Genome biology · 2016

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Summary

DNA methylation contains a significant heritable component that remains consistent across the lifespan. Our results suggest that the genetic component of methylation may have a causal role in complex traits. The database of mQTL presented here provide a rich resource for those interested in investigating the role of methylation in disease.

Source type
Peer-reviewed study
DOI
10.1186/s13059-016-0926-z
Catalogue ID
BFmoef2ocf-zd2aeu
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