Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation

Robert E. Michler, Peter K. Smith, Michael K. Parides, Gorav Ailawadi, Vinod H. Thourani, Alan J. Moskowitz, Michael A. Acker, Judy Hung, Helena Chang, Louis P. Perrault, A. Marc Gillinov, Michael Argenziano, Emilia Bagiella, Jessica Overbey, Ellen Moquete, Lopa Gupta, Marissa A. Miller, Wendy C. Taddei‐Peters, Neal Jeffries, Richard D. Weisel, Eric A. Rose, James S. Gammie, Joseph J. DeRose, John D. Puskas, François Dagenais, Sandra G. Burks, Ismaı̈l El-Hamamsy, Carmelo A. Milano, Pavan Atluri, Pierre Voisine, Patrick T. O’Gara, Annetine C. Gelijns

New England Journal of Medicine · 2016

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Summary

In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients with moderate ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI) or survival after 1 year. Concomitant mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation, but patients had more adverse events. We now report 2-year outcomes.We randomly assigned 301 patients to undergo either CABG alone or the combined procedure. Patients were followed for 2 years for clinical and echocardiographic outcomes.At 2 years, the mean (±SD) LVESVI was 41.2±20.0 ml per square meter of body-surface area in the CABG-alone group and 43.2±20.6 ml per square meter in the combined-proce

Source type
Peer-reviewed study
DOI
10.1056/nejmoa1602003
Catalogue ID
BFmoef2oy5-xygwgh
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