Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Prognostic impact of variant histologies in urothelial bladder cancer treated with radical cystectomy

Francesco Claps, Maaike W. van de Kamp, Roman Mayr, Peter J. Boström, Shahrokh F. Shariat, Katrin Hippe, Simone Bertz, Y. Neuzillet, Joyce Sanders, Wolfgang Otto, Michiel S. van der Heijden, Michael A.S. Jewett, Robert Stöhr, Alexandre R. Zlotta, Carlo Trombetta, Markus Eckstein, Laura S. Mertens, Maximilian Burger, Yanish Soorojebally, Bernd Wullich, Riccardo Bartoletti, François Radvanyi, Nicola Pavan, Nanour Sirab, Maria Carmen Mir, Damien Pouessel, Theodorus van der Kwast, Arndt Hartmann, Yair Lotan, Rossana Bussani, Yves Allory, Bas W.G. van Rhijn

British Journal of Urology · 2023

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Summary

More than 25% of patients harboured a VH at time of RC. Compared to pure UC, clear-cell, plasmacytoid, small-cell and sarcomatoid VHs were associated with worse DSS, while lymphoepithelioma-like VH was characterized by a DSS benefit. Accurate pathological diagnosis of VHs may ensure tailored counselling to identify patients who require more intensive management.

Source type
Peer-reviewed study
DOI
10.1111/bju.15984
Catalogue ID
BFmoef2rp2-6fteu9
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