Malcolm J. Moore, David Goldstein, John Hamm, Arié Figer, J. Randolph Hecht, Steven Gallinger, H. Au, P. Murawa, David Walde, Robert A. Wolff, Daniel de Castro, Robert Lim, Keyue Ding, Gary M. Clark, Theodora Voskoglou-Nomikos, Mieke Ptasynski, Wendy R. Parulekar

doi:10.1200/jco.22.02770

Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group

Malcolm J. Moore, David Goldstein, John Hamm, Arié Figer, J. Randolph Hecht, Steven Gallinger, H. Au, P. Murawa, David Walde, Robert A. Wolff, Daniel de Castro, Robert Lim, Keyue Ding, Gary M. Clark, Theodora Voskoglou-Nomikos, Mieke Ptasynski, Wendy R. Parulekar

Journal of Clinical Oncology · 2023

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Summary

To our knowledge, this randomized phase III trial is the first to demonstrate statistically significantly improved survival in advanced pancreatic cancer by adding any agent to gemcitabine. The recommended dose of erlotinib with gemcitabine for this indication is 100 mg/d.

Source type: Peer-reviewed study
DOI: 10.1200/jco.22.02770
Catalogue ID: BFmoicpf59-eoc6i2

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