Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Fenton reaction‐induced renal carcinogenesis in <i>Mutyh</i>‐deficient mice exhibits less chromosomal aberrations than the rat model

Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni

Pathology International · 2017

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Summary

inactivation; these results were confirmed by a methylation analysis and showed no significant difference between the genotypes. Lymphomas showed a preference for genomic amplifications. Dlk1 inactivation by promoter methylation may be involved in carcinogenesis in both tumors. Fe-NTA-induced murine RCCs revealed significantly less genomic aberrations than those in rats, demonstrating a marked species difference.

Source type
Peer-reviewed study
DOI
10.1111/pin.12598
Catalogue ID
BFmokjns9q-zgagxd
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