Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Conformational regulation of two essential activators of bacterial cell elongation

Morgan S. A. Gilman, Irina Shlosman, Daniel D. Samé Guerra, Masy Domecillo, Elayne M. Fivenson, Claire Bourett, Thomas G. Bernhardt, Nicholas F. Polizzi, Joseph J. Loparo, Andrew C. Kruse

Proceedings of the National Academy of Sciences · 2025

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Summary

as a model, we demonstrate that disrupting these interactions abolishes Rod complex activity in vivo. Our findings reveal the role of MreD in bacterial cell shape determination and highlight its potential as an antibiotic target.

Source type
Peer-reviewed study
DOI
10.1073/pnas.2514198122
Catalogue ID
BFmokjnwrf-zth8w8
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