Physiological responses during ascent to high altitude and the incidence of acute mountain sickness

Alexandra Cobb, Denny Levett, Kay Mitchell, W Aveling, Daniel Hurlbut, Edward T. Gilbert-Kawai, P. J. Hennis, Monty Mythen, Michael P. W. Grocott, Daniel Martín, Caudwell Xtreme Everest, Xtreme Everest 2009, Xtreme Everest 2 investigators, Vineet Ahuja, Golnar Aref-Adib, Robert Burnham, Alexandra Chisholm, Kieran Clarke, David Coates, Matthew Coates, Derek G. Cook, Mark Cox, S Dhillon, C Dougall, Pat Doyle, Pamela W. Duncan, Mark Edsell, Laura Edwards, Lauren Evans, Peter Gardiner, Michael P. W. Grocott, P Gunning, Nicholas Hart, Jane Harrington, John Julian Harvey, C Holloway, Diantha B. Howard, David Hurlbut, Chris Imray, Can İnce, Jildou van der Kaaij, Maryam Khosravi, Nicky Kolfschoten, D Levett, H Luery, Andrew M. Luks, Daniel Martín, Roger McMorrow, Paula Meale, Kay Mitchell, Hugh Montgomery, Gareth J. Morgan, J Morgan, Andrew J. Murray, M Mythen, Stanton Newman, Michael O’Dwyer, James W. Pate, Timothy Plant, Matiram Pun, Paul Richards, Alan Richardson, George W. Rodway, John B. Simpson, Catherine Stroud, M Stroud, J Stygal, Barbara Symons, Piotr Szawarski, A Van Tulleken, Chris van Tulleken, André Vercueil, Liesl Wandrag, Mark H. Wilson, Jeremy S. Windsor, B Basnyat, Caroline S. Clarke, Thomas F. Hornbein, James S. Milledge, James A. West, Sabu Abraham, Tom Adams, W Anseeuw, Rónan Astin, B Basnyat, Oliver Burdall, Janet T. Carroll, Alistair R.M. Cobb, Jonny Coppel, Orestes Couppis, J. H. Court, Andrew F. Cumpstey, Thomas Davies, S Dhillon, Norman G. Diamond, C Dougall, T Geliot, Edward T. Gilbert-Kawai, Grace Gilbert-Kawai, Erich Gnaiger, Michael P. W. Grocott, C Haldane

Physiological Reports · 2021

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Summary

(OR 0.870, p < 0.001) and no previous exposure to altitude >5000 m (OR 2.740, p-value 0.003) predicted the development of moderate-to-severe AMS. The Xtreme Everest Step-Test offers a simple, reproducible field test to help predict AMS, albeit with relatively limited predictive precision.

Source type: Peer-reviewed study
DOI: 10.14814/phy2.14809
Catalogue ID: BFmokjo2bz-3pp0ym

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