Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery

Benjamin O’Brien, Niall Campbell, Elizabeth Allen, Zahra Jamal, Joanna Sturgess, Julie Sanders, Charles Opondo, Neil Roberts, Jonathan Aron, Maria Maccaroni, Richard Gould, Bilal H. Kirmani, Ben Gibbison, Gudrun Kunst, Alexander Zarbock, Maren Kleine‐Brueggeney, Christian Stoppe, Keith Pearce, Mark Hughes, Laura Van Dyck, Richard Evans, Hugh Montgomery, Diana Elbourne, TIGHT K investigators, Robert B. Henderson, Jatin Desai, David Keane, Kurt Ruetzler, Steven Stevenson, R David Martinez Duncker, Rosalie Magboo, Nicholas Barrett, Philip M. Jones, Ly‐Mee Yu, Bob Kiaii, Trudie Lobban, Julie Sanders, Neil Roberts, Sophie Welch, Christabel Williams, Gemma Hughes, Victoria Baker, F.J. Parrondo García, Chrysanthos Sfakianakis, Melissa Baldey, Carmen K. M. Chan, Jorge Couto de Sousa, Hakam Abbass, Niall Campbell, Linda Kimani, Lajos Szentgyörgyi, Louise Rankin, Efstratios Athanasakis, Akhila Muthuswamy, Alison Allanson, Anna Lewis, Arron Finch, Folakemi Fowe, Lahja Paulus, Bisma Chellam Singh, Preetha Mathew, Reshma Dutt Sunil, Jesha Mathews, Sheetal Crasta, Susan M. Ferguson, Schvearn Allen, Seema Pokharel, Anie Nicholas, Adam Pailing, Gudrun Kunst, Harriet Noble, Sian Saha, Kevin O’Reilly, Caitlin Spooner, Emma Clarey, Clare Finney, Anna Broderick, Maria Theresa Depante, Daveena Meeks, Paraskevi Pappa, Laura-Anne Dymore-Brown, Rebecca Samuels, Tajwinder Sandhar, Fatemeh Karami, Annette Axalan, Burt Vergara, Eleanor Corcoran, Mahmoud Loubani, Sarah L. Ford, Kay Rowe, Karen Dobbs, Jeanne Bulemfu, Paul Harper, J. Sanders, Gregory Lip, Bilal H. Kirmani, Maureen Baker, Lynne Keogan, Abinash Panda, Agnieszka Kotalczyk

JAMA · 2024

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Summary

IMPORTANCE: Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used to prevent atrial fibrillation after cardiac surgery (AFACS), but is not evidence-based, carries risks, and is costly. OBJECTIVE: To determine whether a lower serum potassium concentration trigger for supplementation is noninferior to a high-normal trigger. DESIGN, SETTING, AND PARTICIPANTS: This open-label, noninferiority, randomized clinical trial was conducted at 23 cardiac surgical centers in the United Kingdom and Germany. Between October 20, 2020, and November 16, 2023, patients with no history of atrial dysrhythmias scheduled for isolated coronary artery bypass grafting (CABG) surgery were enrolled. The last study patient was discharged from the hospital on Dec

Source type: Peer-reviewed study
DOI: 10.1001/jama.2024.17888
Catalogue ID: BFmokjo2bz-vbry2q

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