Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China

Iona Y. Millwood, Robin Walters, Xue W. Mei, Canqing Yu, Ling Yang, Zheng Bian, Derrick Bennett, Yiping Chen, Caixia Dong, Ruying Hu, Gang Zhou, Bo Yu, Weifang Jia, Sarah Parish, Robert Clarke, George Davey Smith, Rory Collins, Michael V. Holmes, Liming Li, Richard Peto, Zhengming Chen

The Lancet · 2019

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Summary

BACKGROUND: Moderate alcohol intake has been associated with reduced cardiovascular risk in many studies, in comparison with abstinence or with heavier drinking. Studies in east Asia can help determine whether these associations are causal, since two common genetic variants greatly affect alcohol drinking patterns. We used these two variants to assess the relationships between cardiovascular risk and genotype-predicted mean alcohol intake in men, contrasting the findings in men with those in women (few of whom drink). METHODS: The prospective China Kadoorie Biobank enrolled 512 715 adults between June 25, 2004, and July 15, 2008, from ten areas of China, recording alcohol use and other characteristics. It followed them for about 10 years (until Jan 1, 2017), monitoring cardiovascular disea

Source type
Peer-reviewed study
DOI
10.1016/s0140-6736(18)31772-0
Catalogue ID
BFmokjo8sc-27oiru
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