Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

Brian A. Ference, John J.P. Kastelein, Henry N. Ginsberg, M. John Chapman, Stephen J. Nicholls, Kausik K. Ray, Chris J. Packard, Ulrich Laufs, Robert D. Brook, Clare Oliver‐Williams, Adam S. Butterworth, John Danesh, George Davey Smith, Alberico L. Catapano, Marc S. Sabatine

JAMA · 2017

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Summary

Importance: Some cholesteryl ester transfer protein (CETP) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels without reducing cardiovascular events, suggesting that the clinical benefit of lowering LDL-C may depend on how LDL-C is lowered. Objective: To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants in the CETP gene, both alone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene. Design, Setting, and Participants: Mendelian randomization analyses evaluating the association between CETP and HMGCR scores, changes in lipid and lipoprotein levels, and the risk of cardiovascular events involving 102 837 participants from 14 cohort or case-co

Subject
Dietary patterns & chronic disease
Source type
Peer-reviewed study
System type
Other
DOI
10.1001/jama.2017.11467
Catalogue ID
BFmommpgti-n3oyyn
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