Summary
This large cross-sectional analysis of 60,174 Dutch dental patients from the Academic Centre for Dentistry Amsterdam examined the independent association between clinically diagnosed periodontitis and atherosclerotic cardiovascular disease. Periodontitis was significantly associated with ACVD in unadjusted analyses (OR 2.52; 95% CI 2.3–2.8), and this association remained statistically significant after adjustment for major cardiovascular risk factors (OR 1.59; 95% CI 1.39–1.81). The findings suggest periodontitis is an independent risk indicator for ACVD, a relationship that persists across age and sex stratifications.
UK applicability
These findings from a large Dutch cohort are applicable to UK populations given similar healthcare systems and dental epidemiology. The results support consideration of periodontitis assessment as part of cardiovascular risk stratification in UK clinical practice, though causality cannot be inferred from this cross-sectional design.
Key measures
Odds ratios (OR) with 95% confidence intervals for the association between periodontitis and ACVD; unadjusted and adjusted analyses controlling for age, sex, smoking, diabetes, hypertension, hypercholesterolaemia, and socioeconomic status.
Outcomes reported
The study investigated the adjusted association between clinically diagnosed periodontitis and atherosclerotic cardiovascular diseases (ACVD), including cerebrovascular accidents, angina pectoris, and myocardial infarction, among a large cohort of dental patients.
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