Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

SENECA study: staging endometrial cancer based on molecular classification

Enrique Chacón, Félix Boria, R Rajagopalan Lyer, Francesco Fanfani, Mario Malzoni, Petra Bretová, Ana Luzarraga Aznar, Robert Fruscio, Marcin Jędryka, Richárd Tóth, Anna Myriam Perrone, Athanasios Kakkos, Ignacio Cristóbal Quevedo, Luigi Congedo, Vanna Zanagnolo, Sergi Fernández-González, Beatriz Ferro, Fabrice Narducci, T Hovhannisyan, Elif Akşahin, L. M. Cardenas, M Reyes Oliver, Gonzalo Nozaleda, Marta Arnáez, Marcin Misiek, Annamaria Ferrero, F Pain, Janire Zarragoitia, C. Díaz, Lorenzo Ceppi, Shamsi Mehdiyev, Fernando Roldán-Rivas, Alberto Rafael Guijarro‐Campillo, Joana Amengual, Nabil Manzour, Luisa Sánchez‐Lorenzo, Jorge M. Núñez‐Córdoba, Antonio González-Martı́n, José Ángel Mínguez, Luis Chiva, cecilia darin, Rychlik Agnieszka, Ester Miralpeix, Roberto Berretta, Natalia Palasz, Duska Beric, Dimitrios Tsolakidis, Soledad Fidalgo, Richard Schwameis, S. P. Somashekhar, İbrahim Yalçın, Radovan Pilka, Çağatay Taşkıran, Despoina Myoteri, Estibaliz Iza Rodriguez, Dariusz Wydra, Sílvia Catot, Mathias K. Fehr, Frédéric Goffin, María Luisa Ramos Ibarra, Stamatios Petousis, E Moratalla Bartolomé, Mareike Bommert, Alfonso Quesada, Shamistan Aliyev, Sara Iacoponi, Inmaculada Lozano, Krzysztof Nowosielski, Ioannis Kalogiannidis, Lampe Bjourn

International Journal of Gynecological Cancer · 2024

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Summary

The SENECA study, a multi-centre European collaboration, examined molecular classification as a staging tool for endometrial cancer. As suggested by the title and journal context, the research likely assessed whether molecular profiling improves upon conventional histopathological staging for risk stratification and treatment planning in endometrial malignancy. The study's large international consortium reflects growing clinical interest in precision oncology approaches for gynaecological cancers.

UK applicability

Findings on molecular staging of endometrial cancer are directly relevant to UK oncology practice and NHS pathology services. If validated, molecular classification approaches could inform stratification of endometrial cancer patients for treatment intensity and follow-up protocols within UK clinical guidelines.

Key measures

Molecular classification subtypes, staging outcomes, and clinicopathological correlations in endometrial cancer cases

Outcomes reported

The study evaluated molecular classification approaches for staging endometrial cancer across multiple European centres. The research assessed how molecular typing may improve prognostic stratification and clinical management of endometrial malignancies.

Theme
Nutrition & health
Subject
Other / interdisciplinary
Study type
Research
Study design
Observational cohort
Source type
Peer-reviewed study
Status
Published
Geography
Europe
System type
Human clinical
DOI
10.1136/ijgc-2024-005711
Catalogue ID
BFmovbm69e-zvoufz

Topic tags

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