Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

SENECA study: staging endometrial cancer based on molecular classification

Enrique Chacón, Félix Boria, R Rajagopalan Lyer, Francesco Fanfani, Mario Malzoni, Petra Bretová, Ana Luzarraga Aznar, Robert Fruscio, Marcin Jędryka, Richárd Tóth, Anna Myriam Perrone, Athanasios Kakkos, Ignacio Cristóbal Quevedo, Luigi Congedo, Vanna Zanagnolo, Sergi Fernández-González, Beatriz Ferro, Fabrice Narducci, T Hovhannisyan, Elif Akşahin, L. M. Cardenas, M Reyes Oliver, Gonzalo Nozaleda, Marta Arnáez, Marcin Misiek, Annamaria Ferrero, F Pain, Janire Zarragoitia, C. Díaz, Lorenzo Ceppi, Shamsi Mehdiyev, Fernando Roldán-Rivas, Alberto Rafael Guijarro‐Campillo, Joana Amengual, Nabil Manzour, Luisa Sánchez‐Lorenzo, Jorge M. Núñez‐Córdoba, Antonio González-Martı́n, José Ángel Mínguez, Luis Chiva, cecilia darin, Rychlik Agnieszka, Ester Miralpeix, Roberto Berretta, Natalia Palasz, Duska Beric, Dimitrios Tsolakidis, Soledad Fidalgo, Richard Schwameis, S. P. Somashekhar, İbrahim Yalçın, Radovan Pilka, Çağatay Taşkıran, Despoina Myoteri, Estibaliz Iza Rodriguez, Dariusz Wydra, Sílvia Catot, Mathias K. Fehr, Frédéric Goffin, María Luisa Ramos Ibarra, Stamatios Petousis, E Moratalla Bartolomé, Mareike Bommert, Alfonso Quesada, Shamistan Aliyev, Sara Iacoponi, Inmaculada Lozano, Krzysztof Nowosielski, Ioannis Kalogiannidis, Lampe Bjourn

International Journal of Gynecological Cancer · 2024

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Summary

The SENECA study is a large multicentre European observational investigation examining how molecular classification and genomic profiling can refine conventional staging approaches in endometrial cancer. Although primarily a cancer molecular pathology study, it is curated within Vitagri's Pulse Brain because molecular stratification of cancer may inform future personalised dietary and lifestyle interventions at the intersection of precision oncology and precision nutrition. The research contributes foundational understanding of how genomic biomarkers could enable more targeted prognostic assessment and, by extension, support more individualised therapeutic strategies in oncology.

Regional applicability

Findings may be applicable to UK oncology practice and NHS cancer staging protocols, as the study involves European centres and uses standardised molecular classification approaches. Integration of molecular biomarkers into UK endometrial cancer management could inform future precision oncology and nutrition strategies within the NHS.

Key measures

Molecular and genomic biomarkers; conventional staging classification; prognostic stratification outcomes

Outcomes reported

The study examined how molecular classification and genomic profiling can refine conventional staging approaches in endometrial cancer diagnosis and prognosis. The research evaluated molecular stratification as a basis for more targeted prognostic assessment and potential individualised therapeutic strategies.

Theme
Nutrition & health
Subject
Other / interdisciplinary
Study type
Research
Study design
Observational cohort
Source type
Peer-reviewed study
Status
Published
Geography
Europe
System type
Human clinical
DOI
10.1136/ijgc-2024-005711
Catalogue ID
BFmovi1pkk-u5n202

Topic tags

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