Summary
This field trial evaluated the efficacy of five trematocide treatments against concurrent Fasciola gigantica and amphistome infections in cattle from two Tanzanian districts. Nitroxynil, oxyclozanide, closantel and triclabendazole achieved 100% faecal egg count reduction against F. gigantica by day 14, whilst albendazole showed reduced efficacy (49–89% FECR depending on district). Only oxyclozanide was effective against amphistomes, achieving 99% FECR, suggesting differential treatment responses and potential anthelmintic resistance patterns.
UK applicability
While fasciolosis caused by Fasciola gigantica is primarily a tropical problem not established in the UK, the methodological approach and findings on reduced anthelmintic efficacy are relevant to UK livestock systems where Fasciola hepatica resistance to certain trematocides has been documented. The study's evidence of location-specific efficacy variation may inform resistance monitoring strategies.
Key measures
Faecal egg count reduction (FECR) percentage at days 7, 14 and 28 post-treatment; efficacy of five trematocides (albendazole, nitroxynil, oxyclozanide, closantel, triclabendazole) against F. gigantica and amphistomes
Outcomes reported
The study assessed the efficacy of five different trematocide treatments against Fasciola gigantica and amphistome infections in cattle using faecal egg count reduction (FECR) tests over 28 days post-treatment. Efficacy was measured by percentage reduction in faecal egg counts at days 7, 14 and 28 post-treatment.
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