Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Recent advances in the clinical management of intoxication by five heavy metals: Mercury, lead, chromium, cadmium and arsenic.

Balali-Mood M, Eizadi-Mood N, Hassanian-Moghaddam H, Etemad L, Moshiri M, Vahabzadeh M, Sadeghi M.

Heliyon · 2025

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Summary

This narrative review synthesises recent advances in the clinical management of intoxication by five environmentally prevalent heavy metals: mercury, lead, chromium, cadmium and arsenic. The authors, drawn from toxicology and clinical medicine, examine contemporary diagnostic and therapeutic approaches, likely including chelation strategies and supportive management. The work appears positioned to inform clinicians on best-practice management of acute and chronic heavy metal poisoning cases.

UK applicability

Findings are applicable to UK clinical practice where occupational, environmental or dietary exposures to these metals occur. UK poison control services and occupational health practitioners would benefit from contemporary management protocols, though regional exposure patterns and available chelating agents may vary from those emphasised in international guidance.

Key measures

Clinical management protocols, treatment efficacy, toxicokinetics, chelation therapy outcomes, diagnostic biomarkers for heavy metal exposure

Outcomes reported

The paper reviews clinical management strategies and recent advances in treating acute and chronic intoxication from five priority heavy metals: mercury, lead, chromium, cadmium and arsenic. It likely synthesises evidence on diagnostic approaches, chelation therapies, supportive care and toxicokinetic principles relevant to poisoning management.

Theme
Nutrition & health
Subject
Clinical toxicology and heavy metal poisoning management
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.1016/j.heliyon.2025.e42696
Catalogue ID
NRmo3d4gae-039

Topic tags

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