Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Minerals and Human Health: From Deficiency to Toxicity.

Razzaque MS, Wimalawansa SJ.

Nutrients · 2025

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Summary

This narrative review by Razzaque and Wimalawansa examines the relationship between mineral status and human health across the continuum from deficiency to toxicity. The paper likely synthesises evidence on essential minerals (calcium, magnesium, zinc, iron, selenium and others) and their physiological roles, discussing how both insufficient and excessive intake compromise health outcomes. The authors appear to position mineral balance as critical for optimal homeostasis and disease prevention.

UK applicability

UK dietary guidelines and food fortification policies are informed by mineral adequacy thresholds; this review may inform public health messaging on mineral intake targets. Findings are relevant to UK nutrition policy, food industry reformulation, and clinical practice around micronutrient supplementation.

Key measures

Serum and tissue mineral concentrations, dietary intake levels, bioavailability markers, clinical and subclinical disease endpoints associated with mineral deficiency or excess

Outcomes reported

The paper likely reviews the spectrum of mineral status in human populations, from deficiency states through optimal intake to excess and toxicity. It examines how mineral imbalances affect physiological function and disease risk.

Theme
Nutrition & health
Subject
Micronutrient metabolism and human health outcomes
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Human clinical
DOI
10.3390/nu17030454
Catalogue ID
NRmo3d4gae-0bh

Topic tags

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