Pulse Brain · Growing Health Evidence Index
Peer-reviewed

New insight on dietary strategies to increase insulin sensitivity and reduce diabetes prevalence: an expert perspective and recommendation

Fahrul Nurkolis; Dante Saksono Harbuwono; Nurpudji Astuti Taslim; Sidartawan Soegondo; I Ketut Suastika; Roy Alexander Sparringa; Arifa Mustika; Ari Fahrial Syam; Antonello Santini; Jeff M. P. Holly; Arun K. Bhunia; Raymond R. Tjandrawinata

Discover Food · 2025

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Summary

This review investigates dietary strategies aimed at enhancing insulin sensitivity and reducing the risk of type 2 diabetes (T2D), with a special focus on recent meta-analysis evidence supporting the use of probiotics and synbiotics. Dietary interventions, such as the Mediterranean, low-carbohydrate, high-fiber, and plant-based diets, have shown significant promise in modulating glucose metabolism through mechanisms involving insulin receptor activation, glucagon-like peptide 1 (GLP-1) receptor signaling, and peroxisome proliferator–activated receptors (PPARs) regulation. Additionally, probiotics and synbiotics have emerged as complementary approaches, enhancing gut microbiota composition and improving insulin sensitivity through reduced inflammation and oxidative stress. The integration o

Source type
Peer-reviewed study
DOI
10.1007/s44187-025-00422-6
Catalogue ID
NRmo3d4gae-0d2
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