Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans

Susana Langa; José Antonio Curiel; Ruiz de la Bastida; Ángela Peirotén; José María Landete

Journal of the Science of Food and Agriculture · 2025

Read source ↗ All evidence

Summary

Abstract BACKGROUND Plant‐lignans are polyphenols with low bioavailability and bioactivity that are transformed by the intestinal microbiota into enterolignans. Our hypotheses are: (i) the way in which plant‐lignans are ingested in the diet affects, in a decisive way, the microbial metabolism of these compounds and (ii) an increase in lignan bioaccessibility will produce an increase in enterolignans produced by the intestinal microbiota, increasing the bioavailability of lignans ingested in the diet. Therefore, our aims were to determine how the matrix effect affects the metabolism of lignans by the intestinal microbiota and how improving the bioaccessibility of lignans ingested in the diet improves their bioavailability.

Source type
Peer-reviewed study
DOI
10.1002/jsfa.70324
Catalogue ID
NRmo3d4gae-0e2
Pulse AI · ask about this record

Dig deeper with Pulse AI.

Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.