Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Obtainment of Flavonoid-Enriched Fractions from Maqui (Aristotelia chilensis) and Murta (Ugni molinae) Extracts via Preparative HPLC and Evaluation of Their Anti-Inflammatory Effects in Cell-Based Assays

Amador Alburquenque; Carolina Busch; Gabriela Gómez-Lillo; Alexander Gamboa; Camilo Pérez; Nelson Caro Fuentes; Martín Gotteland; Lilian Abugoch; Cristian Tapia

Antioxidants · 2025

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Summary

Polyphenols exert anti-inflammatory and antioxidant effects by modulating cell signalling pathways and transcription factors involved in inflammatory bowel disease (IBD). However, their stability during digestion can be compromised. Polymer coatings like chitosan (-C) help preserve their stability. Maqui (<i>Aristotelia chilensis</i>) and murta (<i>Ugni molinae</i>) are rich in antioxidant and anti-inflammatory compounds. This work aims to obtain extracts (E) and blends (B) enriched in delphinidin and quercetin glucosides from maqui (Ma) and murta (Mu) crude extracts using preparative chromatography methodology (Prep-HPLC) and to evaluate their effectiveness through in vitro and cellular assays. HPLC-DAD analysis revealed a marked increase in phenolic compound concentration in the BEMaMu a

Source type
Peer-reviewed study
DOI
10.3390/antiox14050600
Catalogue ID
NRmo3d4gae-0f2
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