Summary
This randomised crossover clinical trial investigated whether the polyphenol-rich matrix of coffee affects the absorption of signature amino acids and bioactive peptides derived from bovine collagen hydrolysate in healthy humans. Given the known affinity of dietary polyphenols for proline-rich proteins, the study addressed a practically relevant but previously unresolved question about potential matrix-mediated interference with collagen peptide bioavailability. Findings are likely to inform product formulation guidance for collagen-fortified beverages, though any confirmed attenuation or equivalence of absorption would carry direct implications for consumer supplementation practice.
UK applicability
The findings are broadly applicable to UK consumers and practitioners given the widespread and growing use of collagen hydrolysate supplements, including in coffee-based products; no specific geographical barrier limits the relevance of the pharmacokinetic data to a UK population.
Key measures
Plasma amino acid concentrations (hydroxyproline, glycine, proline); plasma bioactive peptide levels (Pro-Hyp, Hyp-Gly, Gly-Pro-Hyp); pharmacokinetic parameters (likely Cmax, Tmax, AUC)
Outcomes reported
The study measured plasma concentrations of hydroxyproline, glycine, and proline, and bioactive peptides (Pro-Hyp, Hyp-Gly, Gly-Pro-Hyp) following ingestion of collagen hydrolysate dissolved in either water or coffee, in healthy adult volunteers.
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