Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Polyphenol-polysaccharide interactions: molecular mechanisms and potential applications in food systems – a comprehensive review

F. Shahidi; Kerthika Devi Athiyappan

Food Production, Processing and Nutrition · 2025

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Summary

This comprehensive narrative review by Shahidi and Athiyappan synthesises current understanding of how polyphenols interact with polysaccharides in food matrices, detailing the molecular forces — including hydrogen bonding, hydrophobic interactions, electrostatic forces, van der Waals forces, and covalent bonds — that govern complex formation. The review evaluates how these interactions modify the stability, bioavailability, and bioactivity of polyphenols, as well as the digestibility of associated macronutrients such as proteins and polysaccharides. It further considers the implications of these interactions for functional food development and the design of delivery systems intended to enhance the efficacy of dietary bioactives.

UK applicability

While this review is not geographically specific, its findings are broadly applicable to UK food science, food formulation, and public health nutrition contexts, particularly in relation to dietary fibre, polyphenol intake from fruit and vegetables, and the development of functional foods aligned with UK dietary guidelines.

Key measures

Binding mechanisms (covalent and non-covalent interactions); bioavailability and bioaccessibility of polyphenols; digestibility of macronutrients; antioxidant and other bioactive properties; structural characterisation of complexes

Outcomes reported

The review examined how covalent and non-covalent interactions between polyphenols and polysaccharides affect bioavailability, stability, digestibility, and biological efficacy of these complexes in food systems. It also assessed potential applications of polyphenol-polysaccharide complexes in food formulation and processing.

Theme
Nutrition & health
Subject
Food biochemistry & bioactive compounds
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Food supply chain
DOI
10.1186/s43014-025-00322-3
Catalogue ID
NRmo3dpodv-00f

Topic tags

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