Summary
This narrative review synthesises evidence on how dietary factors modulate proteomic and metabolomic profiles relevant to chronic kidney disease, drawing on advances in multiomics methodology. It explores the molecular pathways through which dietary components influence renal health, including signalling cascades, metabolic intermediates, and gut-derived metabolites. The authors propose that integrating proteomics and metabolomics data could support a precision nutrition framework for the prevention and management of CKD.
UK applicability
While the review is not geographically specific, its findings are broadly applicable to UK clinical practice and NHS dietary guidance for CKD patients, particularly given the high prevalence of CKD in the UK and growing interest in personalised nutrition approaches within the NHS.
Key measures
Proteomic expression profiles; metabolite concentrations (endogenous and diet-derived); markers of kidney function; dietary pattern associations with CKD risk and progression
Outcomes reported
The review examined how specific dietary components and patterns alter protein expression and metabolite profiles in chronic kidney disease, with a focus on molecular mechanisms linking nutrition to renal function and disease progression. It assessed the utility of multiomics approaches in identifying precision nutrition strategies for CKD management.
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