Pulse Brain · Growing Health Evidence Index
Tier 1 — Meta-analysis / systematic reviewPeer-reviewed

Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

GBD 2023 Disease and Injury and Risk Factor Collaborators.

Lancet · 2025

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Summary

This systematic analysis, produced by the Global Burden of Disease Study 2023 Collaborators, provides comprehensive estimates of morbidity, mortality, and risk-attributable burden for a broad range of diseases, injuries, and behavioural, metabolic, and environmental risk factors across 204 countries and territories over three decades. It is among the most extensive global health surveillance syntheses available, integrating data from thousands of sources to enable cross-national and temporal comparisons. The study likely highlights the continuing and rising contribution of dietary and metabolic risk factors — including poor diet, obesity, and high fasting plasma glucose — to the global burden of non-communicable disease.

UK applicability

The GBD study includes UK-specific estimates, making its findings directly applicable to understanding disease burden, risk factor attribution, and healthy life expectancy trends within the UK. UK policymakers and public health bodies routinely draw on GBD data to inform national strategies on non-communicable disease prevention, dietary guidelines, and health inequality.

Key measures

Disability-adjusted life years (DALYs); years of life lost (YLL); years lived with disability (YLD); healthy life expectancy (HALE); risk-attributable burden by risk factor

Outcomes reported

The study estimated disability-adjusted life years (DALYs), years of life lost, and years lived with disability for 375 diseases and injuries, alongside risk-attributable burden for 88 risk factors. It also reported healthy life expectancy (HALE) across 204 countries and 660 subnational locations from 1990 to 2023.

Theme
Nutrition & health
Subject
Global public health & disease burden
Study type
Systematic Review
Study design
Systematic analysis
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Human clinical
DOI
10.1016/s0140-6736(25)01637-x
Catalogue ID
NRmo3f02hq-05w

Topic tags

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