Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

A comprehensive review of unlocking the potential of lignin-derived biomaterials: from lignin structure to biomedical application.

Zhao J, Zhu M, Jin W, Zhang J, Fan G, Feng Y, Li Z, Wang S, Lee JS, Luan G, Dong Z, Li Y.

J Nanobiotechnology · 2025

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Summary

This comprehensive narrative review, published in the Journal of Nanobiotechnology (2025), synthesises current knowledge on the structure of lignin — a major plant cell wall polymer — and its translation into biomedical biomaterials. It likely covers extraction and modification strategies that yield nanoparticles, hydrogels, and composite scaffolds with properties suitable for drug delivery, antimicrobial applications, and tissue repair. The review is positioned at the intersection of green chemistry and nanomedicine, highlighting lignin's abundance as an agricultural and forestry by-product as a driver for its biomedical valorisation.

UK applicability

The findings are not directly applicable to UK farming or food systems practice, but may be of indirect relevance to UK bioeconomy and agri-industrial policy, given that lignin is a major by-product of UK forestry and lignocellulosic biomass processing. Researchers and industries involved in valorising agricultural residues may find the biomedical applications outlined here relevant to circular economy strategies.

Key measures

Lignin structural features (e.g. monolignol composition, molecular weight); biomaterial properties (e.g. antioxidant activity, biocompatibility, drug loading capacity); biomedical application outcomes (e.g. antimicrobial efficacy, cytotoxicity, in vivo performance)

Outcomes reported

The review likely examines the structural diversity of lignin and how it can be processed or functionalised into biomaterials suitable for biomedical applications, including drug delivery, wound healing, and tissue engineering. It probably assesses the physicochemical properties of lignin nanoparticles and other lignin-based constructs relevant to therapeutic performance.

Theme
Nutrition & health
Subject
Biomaterials & nanomedicine
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.1186/s12951-025-03604-7
Catalogue ID
NRmo3f02hq-062

Topic tags

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