Summary
This narrative review, published in ACS Omega (2025), consolidates current evidence on the role of dietary phytonutrients in the prevention and management of chronic non-communicable diseases. Drawing on a broad literature spanning biochemistry, nutritional epidemiology, and clinical research, the authors likely categorise phytonutrients by compound class and evaluate their mechanisms of action, bioavailability, and therapeutic potential. The paper is positioned as a reference resource for researchers and practitioners working at the intersection of food science and human health.
UK applicability
Whilst this review is international in scope and not UK-specific, its findings are broadly applicable to UK public health priorities, particularly given the high burden of cardiovascular disease, type 2 diabetes, and cancer in the UK population. The evidence on phytonutrient-rich dietary patterns aligns with guidance from bodies such as the NHS and Public Health England encouraging increased fruit, vegetable, and whole food consumption.
Key measures
Bioavailability of phytonutrients; disease risk reduction (cardiovascular disease, type 2 diabetes, cancer incidence); anti-inflammatory and antioxidant biomarkers; mechanistic pathways of action
Outcomes reported
The review examines the evidence base for phytonutrients — including polyphenols, carotenoids, glucosinolates, and flavonoids — in reducing risk and supporting management of chronic diseases such as cardiovascular disease, diabetes, cancer, and inflammatory conditions. It likely synthesises mechanistic pathways and epidemiological or clinical evidence for each compound class.
Topic tags
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