Summary
This paper provides a clinically oriented introduction to the role of autonomic, immune, and endocrine system disruption in the pathophysiology of concussion, with particular attention to cases where symptoms persist beyond the expected recovery period. Drawing on existing literature, the authors propose a treatment framework intended to guide personalised clinical management of post-concussive syndrome. The work contributes to an emerging interdisciplinary approach that moves beyond purely neurological models of concussion recovery.
UK applicability
Whilst this paper is not UK-specific, its clinical framework is applicable to UK practice, including NHS concussion management pathways and sport-related head injury protocols overseen by bodies such as the Concussion in Sport Group. UK clinicians working in neurology, sports medicine, and rehabilitation may find the proposed framework relevant to managing patients with persisting post-concussive symptoms.
Key measures
Autonomic nervous system function; neuroendocrine markers; immune response indicators; symptom persistence profiles; treatment response frameworks
Outcomes reported
The paper examines the physiological mechanisms by which concussion disrupts autonomic, immune, and endocrine functioning, and proposes a treatment framework for patients experiencing persisting post-concussive symptoms. It likely reviews symptom clusters and maps them to underlying system dysregulation to guide clinical management.
Topic tags
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