Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

In vitro release kinetics of bioactive compounds (gallic acid, ellagic acid, and eugenol) from chitosan polymer and the bioactivity of herb-loaded chitosan–CuO nanocomposites

Geethma Ekanayake; Supuni Wijayawardana; Madara Jayanetti; Charitha Thambiliyagodage; Heshan Liyanaarachchi; Amavin Mendis

Scientific Reports · 2025

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Summary

This laboratory-based study investigates how bioactive phenolic compounds — gallic acid, ellagic acid, and eugenol — are released from chitosan polymer carriers over time, and evaluates the bioactivity of nanocomposites combining herb-derived compounds with chitosan and copper oxide (CuO) nanoparticles. The work likely contributes to the development of controlled-release delivery systems with potential antimicrobial and antioxidant applications in food preservation or nutraceutical contexts. Findings are expected to demonstrate that encapsulation within chitosan–CuO matrices modulates compound release and enhances or complements bioactive properties relative to free compounds.

UK applicability

This is a fundamental laboratory study likely conducted in Sri Lanka, with no direct UK agricultural or clinical application; however, its findings on chitosan-based controlled-release systems are broadly relevant to UK food technology, natural preservative research, and nutraceutical delivery innovation.

Key measures

Release kinetics parameters (e.g. cumulative release percentage, release rate constants); antimicrobial inhibition zones or MIC values; nanocomposite characterisation (e.g. particle size, zeta potential, FTIR, XRD)

Outcomes reported

The study measured the in vitro release profiles of gallic acid, ellagic acid, and eugenol from chitosan polymer matrices and assessed the antimicrobial and/or antioxidant bioactivity of herb-loaded chitosan–CuO nanocomposites.

Theme
Nutrition & health
Subject
Food technology & bioactive compound delivery
Study type
Research
Study design
Laboratory experimental study
Source type
Peer-reviewed study
Status
Published
Geography
Sri Lanka
System type
Laboratory / food science
DOI
10.1038/s41598-025-19914-7
Catalogue ID
NRmo3f02hq-0bj

Topic tags

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