Summary
This comprehensive narrative review, published in Signal Transduction and Targeted Therapy in 2025, synthesises current knowledge on Wnt signalling pathways, covering canonical and non-canonical branches, their roles in cell proliferation, differentiation and tissue homeostasis, and their dysregulation in disease. The authors survey therapeutic advances targeting Wnt components, likely encompassing small molecules, biologics and emerging modalities across oncology and other disease areas. As a high-impact review in a leading translational journal, it is likely to serve as a reference resource for researchers and clinicians working on Wnt-related biology and drug development.
UK applicability
This is a biomedical review with global applicability; UK researchers in oncology, developmental biology and drug discovery will find it relevant, particularly in the context of NICE-guided treatment development and UK clinical trials targeting Wnt-driven malignancies.
Key measures
Wnt pathway components and regulatory mechanisms; disease associations; therapeutic agents in development or clinical use; mechanistic evidence from preclinical and clinical studies
Outcomes reported
The review examines the molecular mechanisms of Wnt signalling pathways, their roles in development, homeostasis and disease (including cancer, metabolic and degenerative conditions), and the current landscape of therapeutic strategies targeting these pathways.
Topic tags
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