Summary
This review, published in Signal Transduction and Targeted Therapy in 2025, synthesises evidence on the molecular and cellular mechanisms linking biological ageing to the pathogenesis of neurodegenerative diseases, and appraises antiageing strategies under investigation for therapeutic application. The authors likely draw on a broad body of preclinical and clinical literature to identify convergent pathways — such as senescence, autophagy dysregulation, and oxidative stress — that represent tractable intervention targets. The paper appears to provide a translational framework mapping mechanistic insights to clinical advances, serving as a reference for researchers and clinicians working on neurodegeneration.
UK applicability
Whilst the review is international in scope and not UK-specific, its findings are directly applicable to UK health policy and clinical research priorities given the significant burden of dementia and age-related neurological conditions on the NHS and UK society; UK research bodies such as Alzheimer's Research UK and the NIHR are active in the areas covered.
Key measures
Mechanistic pathways of ageing (e.g. cellular senescence, mitochondrial dysfunction, proteostasis failure, neuroinflammation); clinical trial outcomes for antiageing interventions; translational progress from preclinical models to human studies
Outcomes reported
The paper reviews biological mechanisms underlying ageing as a driver of neurodegenerative diseases and evaluates current and emerging antiageing interventions — including pharmacological, genetic, and lifestyle-based approaches — with respect to their potential clinical utility in conditions such as Alzheimer's and Parkinson's disease.
Topic tags
Dig deeper with Pulse AI.
Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.