Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

The global and regional burden of diabetic peripheral neuropathy.

Savelieff MG, Elafros MA, Viswanathan V, Jensen TS, Bennett DL, Feldman EL.

Nat Rev Neurol · 2025

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Summary

This review, published in Nature Reviews Neurology, synthesises current evidence on the global and regional epidemiological burden of diabetic peripheral neuropathy (DPN), one of the most common and disabling complications of diabetes mellitus. Authored by a prominent international group of neuropathy researchers, it likely examines how DPN prevalence and impact differ across regions, with particular attention to under-resourced settings where diagnosis and management remain limited. The paper is expected to highlight the substantial and growing public health challenge posed by DPN in the context of rising global diabetes rates.

UK applicability

Whilst this is a global review, findings are directly relevant to the UK given the high and rising prevalence of type 2 diabetes within the NHS population and existing inequalities in diabetes complication rates across ethnic and socioeconomic groups. UK clinicians and public health policymakers may draw on regional burden data to inform screening and care pathway prioritisation.

Key measures

Prevalence (%), incidence rates, disability-adjusted life years (DALYs) or comparable burden metrics, regional variation in neuropathy burden, risk factor associations

Outcomes reported

The paper likely reports on the global and regional prevalence, incidence, and disability burden of diabetic peripheral neuropathy, examining how this complication varies across world regions and populations. It probably also considers risk factors, diagnostic challenges, and disparities in disease burden between high- and low-income settings.

Theme
Nutrition & health
Subject
Diabetes & metabolic disease complications
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Human clinical
DOI
10.1038/s41582-024-01041-y
Catalogue ID
NRmo3f02hq-0c8

Topic tags

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