Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

The role of nutritional vitamin D in chronic kidney disease–mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation—a European consensus statement

Hanne Skou Jørgensen; Marc Vervloet; Étienne Cavalier; Justine Bacchetta; Martin H. de Borst; Jordi Bover; Mario Cozzolino; Ana Carina Ferreira; Ditte Hansen; Markus Herrmann; Renate de Jongh; Sandro Mazzaferro; Mandy Wan; Rukshana Shroff; Pieter Evenepoel

Nephrology Dialysis Transplantation · 2025

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Summary

This European consensus statement, produced jointly by the European Renal Osteodystrophy initiative of the European Renal Association and the European Society for Paediatric Nephrology, synthesises evidence on nutritional vitamin D supplementation in CKD patients across all stages, including those on dialysis and following kidney transplantation. The expert panel addresses the clinical rationale for vitamin D screening and correction in the context of recent large-scale trials that questioned the benefit of supplementation in the general population. The resulting clinical practice points are intended to guide clinicians managing CKD-mineral and bone disorder in both children and adults.

UK applicability

The consensus statement is directly applicable to UK clinical practice, as UK nephrologists operate within European clinical frameworks and the guidance covers populations managed under NHS renal services; UK clinicians should consider these recommendations alongside NICE and KDIGO guidance on CKD-MBD management.

Key measures

Serum 25-hydroxyvitamin D concentrations; clinical practice recommendations; skeletal and non-skeletal outcomes; CKD-mineral and bone disorder (CKD-MBD) parameters

Outcomes reported

The consensus statement evaluates the evidence for screening and correcting vitamin D deficiency across CKD stages, dialysis, and post-transplantation, formulating clinical practice points for both paediatric and adult populations. It considers skeletal and non-skeletal outcomes in light of recent large-scale trial evidence.

Theme
Nutrition & health
Subject
Renal nutrition & bone metabolism
Study type
Guideline
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
Europe
System type
Human clinical
DOI
10.1093/ndt/gfae293
Catalogue ID
NRmo3f02hq-0df

Topic tags

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