Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Reactive oxygen species (ROS): sources, generation, disease pathophysiology, and antioxidants

Waseem Ahmad Ansari; Kajal Srivastava; Malik Nasibullah; Mohammad Faheem Khan

Discover Chemistry. · 2025

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Summary

Reactive oxygen species (ROS) are widely known as highly reactive signalling and transcription factors. They have shown beneficial effects at low concentrations to regulate multiple cellular processes like proliferation, differentiation, migration, necrosis, and autophagy. Elevated levels of ROS destroys the physiological functions by cross-linking with lipids, protein, and DNA, which lead to several diseases, including cancer, cardiovascular, diabetes, arthritis, neurological disorders and others metabolic diseases. Thus, quenching of excess ROS is very necessary to counter their deleterious effects. To deplete their increased concentration, there are so many endogenous as well as exogenous antioxidants are available, including both enzymatic and non-enzymatic antioxidants. In this review

Source type
Peer-reviewed study
DOI
10.1007/s44371-025-00275-z
Catalogue ID
NRmo918ux4-003
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