Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Exploring Deep Eutectic Solvents as Pharmaceutical Excipients: Enhancing the Solubility of Ibuprofen and Mefenamic Acid

Mihaela-Alexandra Nica; Valentina Anuța; Cristian Andi Nicolae; Lăcrămioara Popa; Mihaela Violeta Ghica; Florentina-Iuliana Cocoș; Cristina‐Elena Dinu‐Pîrvu

Pharmaceuticals · 2024

Read source ↗ All evidence

Summary

<b>Objectives</b>: The study explores the potential of various deep eutectic solvents (DESs) to serve as drug delivery systems and pharmaceutical excipients. The research focuses on two primary objectives: evaluating the ability of the selected DES systems to enhance the solubility of two poorly water-soluble model drugs (IBU and MFA), and evaluating their physicochemical properties, including density, viscosity, flow behavior, surface tension, thermal stability, and water dilution effects, to determine their suitability for pharmaceutical applications. <b>Methods</b>: A range of DES systems containing pharmaceutically acceptable constituents was explored, encompassing organic acid-based, sugar- and sugar alcohol-based, and hydrophobic systems, as well as menthol (MNT)-based DES systems wi

Source type
Peer-reviewed study
DOI
10.3390/ph17101316
Catalogue ID
NRmo9zxr64-09c
Pulse AI · ask about this record

Dig deeper with Pulse AI.

Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.