An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)
Michèle Vacca; Ioannis Kamzolas; Lea Mørch Harder; Fiona Oakley; Christian Trautwein; Maximilian Hatting; Trenton T. Ross; Barbara Bernardo; Anouk Oldenburger; Sara Toftegaard Hjuler; Iwona Ksiazek; Daniel Lindén; Detlef Schuppan; Sergio Rodríguez‐Cuenca; Maria Manuela Tonini; Tamara R. Castañeda; Aimo Kannt; Cecília M. P. Rodrigues; Simon Cockell; Olivier Govaere; Ann K. Daly; Michael Allison; Kristian Honnens de Lichtenberg; Yong Ook Kim; Anna Lindblom; Stephanie Oldham; Anne‐Christine Andréasson; Franklin Schlerman; Jonathon Marioneaux; Arun J. Sanyal; Marta B. Afonso; Ramy Younes; Yuichiro Amano; Scott L. Friedman; Shuang Wang; Dipankar Bhattacharya; Eric J. Simon; Valérie Paradis; Alastair D. Burt; Ioanna Maria Grypari; Susan Davies; Ann Driessen; Hiroaki Yashiro; Susanne Elisabeth Pors; M Andersen; Michael Feigh; Carla Yunis; Pierre Bédossa; Michelle Stewart; Heather Cater; Sara Wells; Jörn M. Schattenberg; Quentin M. Anstee; The LITMUS Investigators; Quentin M. Anstee; Ann K. Daly; Simon Cockell; Dina Tiniakos; Pierre Bédossa; Alastair D. Burt; Fiona Oakley; Heather J. Cordell; Christopher P. Day; Kristy Wonders; Paolo Missier; Matthew McTeer; Luke Vale; Yemi Oluboyede; Matt Breckons; Jo Boyle; Patrick M. Bossuyt; Hadi Zafarmand; Yasaman Vali; Jenny Lee; Max Nieuwdorp; Adriaan G. Holleboom; Athanasios Angelakis; Joanne Verheij; Vlad Ratziu; Karine Clément; Rafael Patiño‐Navarrete; Raluca Pais; Valérie Paradis; Detlef Schuppan; Jörn M. Schattenberg; Rambabu Surabattula; Sudha Rani Myneni; Yong Ook Kim; Beate K. Straub; Antonio Vidal-Puig; Michèle Vacca; Sergio Rodrigues-Cuenca; Mike Allison; Ioannis Kamzolas; Evangelia Petsalaki; Mark Campbell; Chris Lelliott; Susan Davies; Matej Orešič; Tuulia Hyötyläinen
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, encompasses steatosis and metabolic dysfunction-associated steatohepatitis (MASH), leading to cirrhosis and hepatocellular carcinoma. Preclinical MASLD research is mainly performed in rodents; however, the model that best recapitulates human disease is yet to be defined. We conducted a wide-ranging retrospective review (metabolic phenotype, liver histopathology, transcriptome benchmarked against humans) of murine models (mostly male) and ranked them using an unbiased MASLD 'human proximity score' to define their metabolic relevance and ability to induce MASH-fibrosis. Here, we show that Western diets align closely with human MASH; high cholesterol content, extended study
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