Pulse Brain · Growing Health Evidence Index
Peer-reviewed

A specialized metabolic network selectively modulates <i>Arabidopsis</i> root microbiota

Ancheng C. Huang, Ting Jiang, Yongxin Liu, Yuechen Bai, Yuechen Bai, James Reed, Baoyuan Qu, Alain Goossens, Hans‐Wilhelm Nützmann, Yang Bai, Yang Bai, Anne Osbourn

Science · 2019

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Summary

Plant specialized metabolites have ecological functions, yet the presence of numerous uncharacterized biosynthetic genes in plant genomes suggests that many molecules remain unknown. We discovered a triterpene biosynthetic network in the roots of the small mustard plant <i>Arabidopsis thaliana.</i> Collectively, we have elucidated and reconstituted three divergent pathways for the biosynthesis of root triterpenes, namely thalianin (seven steps), thalianyl medium-chain fatty acid esters (three steps), and arabidin (five steps). <i>A. thaliana</i> mutants disrupted in the biosynthesis of these compounds have altered root microbiota. In vitro bioassays with purified compounds reveal selective growth modulation activities of pathway metabolites toward root microbiota members and their biochemi

Source type
Peer-reviewed study
DOI
10.1126/science.aau6389
Catalogue ID
SNmoh7jcxo-6byyzi
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