Summary
The high level of inherent drug resistance of <i>Mycobacterium abscessus</i> makes the infection caused by it very difficult to be treated. The objective of this study was to evaluate the potential of nosiheptide (NOS) as a new drug candidate for treating <i>M. abscessus</i> infections. The microplate AlamarBlue assay was performed to determine the minimum inhibitory concentrations (MICs) of NOS for 28 reference strains of rapidly growing mycobacteria (RGM) and 77 clinical isolates of <i>M. abscessus</i>. Time-kill kinetic and post-antibiotic effect (PAE) of NOS against <i>M. abscessus</i> was evaluated. Its bactericidal activity against <i>M. abscessus</i> in macrophages was determined by an intracellular colony numerating assay. NOS manifested good activity against the reference strains
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