Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies

Iosif Xenogiannis, Marco Zenati, Deepak L. Bhatt, Sunil V. Rao, Josep Rodés‐Cabau, Steven Goldman, Kendrick Shunk, Kreton Mavromatis, Subhash Banerjee, Khaldoon Alaswad, Ilias Nikolakopoulos, Evangelia Vemmou, Judit Karácsonyi, Dimitrios Alexopoulos, M. Nicholas Burke, Vinayak Bapat, Emmanouil S. Brilakis

Circulation · 2021

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Summary

Saphenous vein grafts (SVGs) remain the most frequently used conduits in coronary artery bypass graft surgery (CABG). Despite advances in surgical techniques and pharmacotherapy, SVG failure rates remain high, often leading to repeat coronary revascularization. The no-touch SVG harvesting technique (minimal graft manipulation with preservation of vasa vasorum and nerves) reduces the risk of SVG failure, whereas the effect of the off-pump technique on SVG patency remains unclear. Use of buffered storage solutions, intraoperative graft flow measurement, careful selection of the target vessels, and physiological assessment of the native coronary circulation before CABG may also reduce the incidence of SVG failure. Perioperative aspirin and high-intensity statin administration are the cornerst

Source type
Peer-reviewed study
DOI
10.1161/circulationaha.120.052163
Catalogue ID
SNmoh9ms5x-tghs9k
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