Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Novel Combined Antioxidant Strategy against Hypertension, Acute Myocardial Infarction and Postoperative Atrial Fibrillation

Ramón Rodrigo, Jaime González‐Montero, Camilo G. Sotomayor

Biomedicines · 2021

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Summary

Reactive oxygen species (ROS) play a physiological role in the modulation of several functions of the vascular wall; however, increased ROS have detrimental effects. Hence, oxidative stress has pathophysiological impacts on the control of the vascular tone and cardiac functions. Recent experimental studies reported the involvement of increased ROS in the mechanism of hypertension, as this disorder associates with increased production of pro-oxidants and decreased bioavailability of antioxidants. In addition, increased ROS exposure is found in ischemia-reperfusion, occurring in acute myocardial infarction and cardiac surgery with extracorporeal circulation, among other settings. Although these effects cause major heart damage, at present, there is no available treatment. Therefore, it shoul

Source type
Peer-reviewed study
DOI
10.3390/biomedicines9060620
Catalogue ID
SNmoh9mtnt-dbu2k4
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