Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Association of Triglyceride-Lowering <i>LPL</i> Variants and LDL-C–Lowering <i>LDLR</i> Variants With Risk of Coronary Heart Disease

Brian A. Ference, John J.P. Kastelein, Kausik K. Ray, Henry N. Ginsberg, M. John Chapman, Chris J. Packard, Ulrich Laufs, Clare Oliver‐Williams, Angela Wood, Adam S. Butterworth, Emanuele Di Angelantonio, John Danesh, Stephen J. Nicholls, Deepak L. Bhatt, Marc S. Sabatine, Alberico L. Catapano

JAMA · 2019

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Summary

Triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants were associated with similar lower risk of CHD per unit difference in ApoB. Therefore, the clinical benefit of lowering triglyceride and LDL-C levels may be proportional to the absolute change in ApoB.

Source type
Peer-reviewed study
DOI
10.1001/jama.2018.20045
Catalogue ID
SNmohbb3hh-gb30k8
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