Pulse Brain · Growing Health Evidence Index
Peer-reviewed

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft, Colin Freeman, Desislava Petkova, Gavin Band, Lloyd T. Elliott, Kevin Sharp, Allan Motyer, Damjan Vukcevic, Olivier Delaneau, Jared O’Connell, Adrián Cortés, Samantha Welsh, A. P. Young, Mark Effingham, Gil McVean, Stephen Leslie, Naomi E. Allen, Peter Donnelly, Jonathan Marchini

Nature · 2018

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Summary

The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. The open resource is unique in its size and scope. A rich variety of phenotypic and health-related information is available on each participant, including biological measurements, lifestyle indicators, biomarkers in blood and urine, and imaging of the body and brain. Follow-up information is provided by linking health and medical records. Genome-wide genotype data have been collected on all participants, providing many opportunities for the discovery of new genetic associations and the genetic bases of complex traits. Here we describe the centralized analysis of the genetic data, incl

Source type
Peer-reviewed study
DOI
10.1038/s41586-018-0579-z
Catalogue ID
SNmohi6g1u-tjzwrj
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